Of note that the small sample analysed by Lien et al. indicates a concordance with differentially regulated genes in the MCF-7 EP300 signature, downregulation of CDH1, CEACAM6 and ARHGAP8, another Rho GTPase-activating protein, as well as upregulation of BCL2A1, EFNB1 (ephrin B1) and osteoprotegerin (TNFRSF11B), a soluble TRAIL decoy receptor secreted by inflammatory and invasive breast cancer cells that induces aneuploidy, cell proliferation and angiogenesis [53]. This evidence concerns the gene ARHGAP8 and breast cancer.