According to the 2006 revised international classification criteria [2], patients with definite diagnosis of APS are those presenting positive lupus anticoagulant (LAC) and/or one among anti-cardiolipin (aCL) IgG or IgM or anti-beta2 glycoprotein I (aβ2GPI) IgG or IgM antibodies. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.