Moreover, CCN1 was necessary for interleukin-17 (IL)-17-induced fibroblast-like synoviocytes proliferation18 and promotes proinflammatory cytokine IL-1β production during the progression of RA disease19, and enhances VEGF-A-dependent angiogenesis in RA process20. The gene discussed is CCN1; the disease is rheumatoid arthritis.