A link between NRAS gain and lung metastasis is plausible, since both occur across human cancer types (Forbes et al, 2015), NRAS mutations/gain occurs prior to the onset of metastasis in melanoma (Edlundh‐Rose et al, 2006; Colombino et al, 2012), and since NRAS mutations/gain is especially frequent in cancers that commonly home to the lungs (i.e. melanoma, thyroid and colon adenocarcinomas, acute myeloid leukemia, and metastatic tumors of unknown primary). Here, NRAS is linked to metastatic neoplasm.