NRAS and neoplasm: In addition to identifying a connection between NRAS and lung metastasis, our data provide mechanistic clues on the stage of the metastatic process at which NRAS mutation/gain becomes pivotal (Valastyan & Weinberg, 2011; Vanharanta & Massague, 2013): The oncogene appears to be dispensable for tumor cell dissemination from the primary tumor, but to be cardinal for homing of circulating tumor cells to the lungs.