Similar to other known paracrine molecular targets of RAS that have been shown to foster extravasation (Rak et al, 2000; Gupta et al, 2007; Qian et al, 2011), we show that NRAS impacts tumor cell homing to the lungs likely via CXCR1/2 signaling. The gene discussed is CXCR1; the disease is neoplasm.