Although the functional association of NRAS mutations/gain with metastatic propensity merits further investigation and is likely linked to both cell‐autonomous and paracrine signaling of cancer cells (Valastyan & Weinberg, 2011; Vanharanta & Massague, 2013), our results support that pulmonary tropism induced by mutant NRAS is predominantly mediated via tumor–host interactions in vivo. This evidence concerns the gene NRAS and neoplasm.