Terao et al. [26] demonstrated a significant elevation in the brain tissue, not plasma, levels of RANTES wild-type mice (WT) subjected to focal cerebral ischemia–reperfusion (I/R), we report an elevation of plasma 837.36 ρg/ml and brain tissue 237.39 ρg/ml RANTES level following injury. Here, CCL5 is linked to brain ischemia.