The decline in the 5th day RANTES levels from 923.1 (409.3–1291.0) on admission to 786.2 (83.5–1804.7) in severe head injury group was observed, likely due to the onset of sepsis, as the association of the down-regulation of RANTES levels with infection is well established in pediatric and adult population [14–16]. The gene discussed is CCL5; the disease is infection.