Interestingly, the third-ranked DMR genome-wide (Additional file 1: Figure S1) was located in the first intron of C9orf3 (chr9:97,504,001–97,504,500), which has been associated with polycystic ovary syndrome in women [34] and development of erectile dysfunction after radiotherapy for prostate cancer in men [35]. The gene discussed is AOPEP; the disease is prostate cancer.