Demyelination occurred later in slices treated with NMO#53 + HC, with a 36.6 ± 5.1% loss beginning at 12 h (p < 0.01), and reaching 62.3 ± 9.0% (p < 0.001) MBP loss at 48 h (Fig. 3p). The gene discussed is MBP; the disease is neuromyelitis optica.