ABCG2 and non-small cell lung carcinoma: Thus, the aim of the present study was to test the following hypotheses: (i) Expression of ABC transporters are different in AC and SCC subtypes of NSCLC patients due to the highly diverse Wnt microenvironment; and (ii) Differential expression and functionality of ABCB1 and ABCG2 are directly regulated by cisplatin modified Wnt signaling leading to altered response to second in line drugs.