ABCB1 and non-small cell lung carcinoma: The present study using resected tissues of primary NSCLC subtypes and an in vitro tissue aggregate model of the lung has provided the following information: a) ABCB1 and ABCG2 drug transporters are expressed differentially in AC and SCC tissues, b) drug transporter transcription is affected differentially by cisplatin, paclitaxel, doxorubicin and gemcitabine, and c) and apart from cisplatin, none of the studied drugs increased ABCC1 message levels indicating that in vitro determination of recommended drug administration sequences can be determined to aid more favorable clinical outcome.