qRT-PCR tests revealed that gemcitabine triggered a significant increase in ABCB1 and ABCC2 expression both in adeno and squamous cell carcinoma tissues (Fig. 4a, b) while paclitaxel and doxorubicin differentially initiated drug transporter transcription (Fig. 4a, b). The gene discussed is ABCC2; the disease is squamous cell carcinoma.