Thus, the aim of the present study was to test the following hypotheses: (i) Expression of ABC transporters are different in AC and SCC subtypes of NSCLC patients due to the highly diverse Wnt microenvironment; and (ii) Differential expression and functionality of ABCB1 and ABCG2 are directly regulated by cisplatin modified Wnt signaling leading to altered response to second in line drugs. Here, ABCB1 is linked to non-small cell lung carcinoma.