WNT7B and malignant colon neoplasm: As cisplatin increased the canonical Wnt7b in the study, increase of ABCB1 and ABCG2 perhaps is not surprising as previous studies have also demonstrated beta-catenin dependent induction of ABCB1 [37, 38] in breast cancer [39, 40] and ABCG2 in colon cancer [41].