However, in both CN-AML and APL there was also downregulation of about 20 cell cycle promoting genes, including Cyclin E1 in CN-AML, Cyclins A2, B1 and B2 in both CN-AML and APL and CDC2 in APL (Fig. 2a and b). The gene discussed is CCNE1; the disease is acute promyelocytic leukemia.