However, our bioinformatic analysis revealed that p53 is not functional as an activating transcription factor in CN-AML and APL blasts as we did not find induction of genes related to various p53-functional outcomes, cell cycle arrest, apoptosis, DNA repair and oxidative stress defense (Additional files 8, 10, 11, 12). The gene discussed is TP53; the disease is acute myeloid leukemia.