BIK and acute promyelocytic leukemia: First, we analyzed DEGs that are related to the Bcl2 family and found a significant upregulation of the anti-apoptotic Bcl-2 and Bcl-xL genes in CN-AML and APL respectively, accompanied by a downregulation of proapoptotic genes, Bid in both subtypes and Bik and Bim in CN-AML.