NOS2 and Alzheimer disease: The IL-1β is a potent neuroimmune mediator that takes effect on various cell types including neurons and microglia [38]; iNOS expression is elevated in activated microglia with its synthetic product nitric oxide being one of the major causes of neurodegenerative diseases [39]; and the expression of IL-6 is also strongly linked to AD as an inflammatory mediator [40, 41].