CAF typically display enhanced expression of structural proteins as alpha-smooth muscle actin (α-SMA), vimentin and fibroblast specific protein 1 (FSP-1), and secrete high amounts of cytokines and growth factors directly involved in MM pathogenesis, such as interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), fibroblast growth factor-2 (FGF-2), and hepatocyte growth factor (HGF). This evidence concerns the gene VEGFA and Miyoshi myopathy.