AKT1 and Familial prostate cancer: Furthermore, these three genes are all involved in four KEGG [36] pathways: hsa05215: Prostate cancer (p-value=1.5E-4), hsa05206: MicroRNAs in cancer (p-value=1.7E-3), hsa04151: PI3K-Akt signaling pathway (p-value=2.5E-3) and hsa05200: Pathways in cancer (p-value=3.2E-3) as revealed by the DAVID functional annotation tool [37, 38].