ZEB1 and neoplasm: Downregulation of miR-200a, which was found in benign meningiomas compared to arachnoidal tissue, leads to an increased protein level of its direct targets i.e. the transcriptional repressors ZEB1 (zinc finger E-box binding homeobox 1) and SIP1/ZEB2 (zinc finger E-box binding homeobox 2), which in turn decreases transcription of E-cadherin, thereby promoting tumor growth and invasion [11].