In esophageal squamous cell carcinoma (ESCC), overexpression of FRAT1 is associated with increased cell proliferation and aberrant activation of the β-catenin/TCF pathway, a consequence of nuclear accumulation of β-catenin that promotes the transcriptional activity of β-catenin/TCF [34]. Here, FRAT1 is linked to esophageal squamous cell carcinoma.