PARP1 and endothelial dysfunction: Although the hyper-reactivity of SHR vessels to SNP was not affected by L-2286 treatment in a significant manner (Fig 1D), the above results indicate that endothelial NO production and response may be impaired in SHR animals, resembling previous observations in this model regarding the role of PARP-1 activation in the evolution of endothelial dysfunction [17].