Additionally, cardiac specific over-expression of adhesion proteins such as N-cadherin, E-cadherins or the Coxsackie-Adenovirus-receptor (CAR) also cause heart failure in mice [42, 43], suggesting that cardiomyocyte adhesion is sensitively controlled, dosage dependent, and needs fine-tuning and adjustments by different adhesion proteins. Here, CDH2 is linked to heart failure.