In our study, subjects with TC heterozygotes of the SERPINB5 rs17071138 polymorphism and who were areca nut, alcohol, or tobacco consumers had respective 4.26-, 2.34-, and 2.34-fold significantly increased risks of developing oral cancer compared to those with WT TT homozygotes of SERPINB5 rs17071138, after adjusting for confounding factors. The gene discussed is SERPINB5; the disease is lip and oral cavity carcinoma.