SERPINB5 and lip and oral cavity carcinoma: Individuals with the rs17071138 TT WT homozygotes had higher SERPINB5 gene expression, which contributed to inhibition of oral cancer development; however, individuals with heterozygotes TC of the SERPINB5 rs17071138 polymorphism exhibited decreased SERPINB5 protein function or expression, which contributed to a lack of response to oncogene-induced senescence and consequently promoted the development of oral cancer [17, 23–30].