Moreover, gene-to-gene interactions significantly increased the risk of oral cancer susceptibility among participants with TC or CC of rs17071138, CT or TT of rs3744941, and CT or CC of rs8089104 polymorphisms of SERPINB5. It was demonstrated that oncogene-induced senescence contributed to repressing aberrant proliferation of oral squamous cells at risk of neoplastic transformation [11, 12]. The gene discussed is SERPINB5; the disease is lip and oral cavity carcinoma.