The individuals who are heterozygous for a rs17071138 TC polymorphism and with CC homozygotes of the SERPINB5 rs8089104 polymorphism had 1.57- (95% CI: 1.07~2.31; p = 0.01) and 1.58-fold (95% CI: 1.04~2.39; p = 0.02) greater risks of developing oral cancer, respectively, compared to those with wild-type homozygotes of SERPINB5 rs17071138 TT and SERPINB5 rs8089104 TT after adjusting for confounding factors. The gene discussed is SERPINB5; the disease is lip and oral cavity carcinoma.