The individuals who are heterozygous for a TC polymorphism of the SERPINB5 rs17071138 polymorphism had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) increased risks of developing oral cancer compared to those with WT homozygotes TT of SERPINB5 rs17071138 among areca nut, alcohol, and tobacco consumers, respectively, after adjusting for confounding factors (Table 2). The gene discussed is SERPINB5; the disease is lip and oral cavity carcinoma.