The present finding of abnormal glycerophospholipids such as choline in TM-domain Nrg1 mutant mice, taken together with the evidence that the endocannabinoid system is dysregulated in schizophrenia,85 highlight the importance of further research to advance our understanding of the mechanisms underlying the interaction between NRG1, the endocannabinoid system, and schizophrenia. This evidence concerns the gene NRG1 and schizophrenia.