In addition, on a background of reports of up-regulation of NRG1 protein and increased NRG1 signaling in schizophrenia patients,4 neonatal, peripheral administration of NRG1 type 1 protein in mice has been shown to produce adult deficits in PPI and LI using a fear conditioning task, which were reversed by antipsychotic treatment.47 The present study demonstrated intact LI in Nrg1 mutants, with male Nrg1 mutants exhibiting a nonspecific decrease in suppression ratios across both the pre-exposed and non–pre-exposed conditions. This evidence concerns the gene NRG1 and schizophrenia.