Patients with schizophrenia are at increased risk for metabolic abnormalities,96,97 and several antipsychotic drugs, particularly clozapine and olanzapine, can cause adverse effects that are related to lipid metabolism (eg, weight gain, insulin resistance).44,98 This study has identified novel physiological mechanisms by which disruption of NRG1 function might contribute to the emergence of schizophrenia-relevant phenotypes in adulthood. Here, INS is linked to schizophrenia.