Among the PDE family of enzymes, those belonging to the PDE4 subfamily are the best characterized, due to their role as the main negative regulator of cellular cyclic AMP in the CNS [35], their key activity in maintaining cyclic AMP signal compartmentalization [140,141] and their implicated involvement in a wide range of neurological diseases and injury [30,45,142,143,144,145,146,147]. This evidence concerns the gene PDE4A and nervous system disorder.