CDC42EP3 and cancer: The pro-migratory effect of long septin filaments associated to actin filaments is not limited to cancer cells in tumors and a recent study showed that over-expression of CEP3 (Cdc42 Effector Protein 3 or Borg2), a regulator of septins, induced the assembly of small septin polymers in longer filaments associated with stress fibers, which transformed normal fibroblasts in the more motile and invasive cancer-associated fibroblasts (CAFs)37.