To explore the biological role of CREB3L4 in prostate cancer, we first observed the expression level of CREB3L4 in prostate cancer cell lines, including the androgen-dependent prostate cancer (ADPC) cell line LNCaP, the androgen-insensitive metastatic subline C4-2B (derived from parental ADPC LNCaP cells), the androgen-independent prostate cancer (AIPC) cell line PC-3, and the nontumorigenic prostatic epithelial cell line RWPE-1. Here, CREB3L4 is linked to Familial prostate cancer.