Given the hypothesized modulating role of APOE genotype status on WM microstructure and connectivity13, we tested for differences between carriers and non-carriers of the APOE ε4 risk allele within and across groups, and also tested if carriers would show more AD-like WM characteristics by comparing the AD classifier’s decision probability between carriers and non-carriers in the SCI and MCI groups. The gene discussed is APOE; the disease is Alzheimer disease.