APOE and Alzheimer disease: When comparing the classification probability obtained using all LICA features, for the classification of AD vs. MCI, the results show a trend that MCI non-carriers of APOE ε4 (n = 23) were given a higher probability of being correctly classified as MCI than the carriers (n = 18, Cohen’s d = 0.55, t = 1.62, p = 0.12, Supplementary Fig. S9).