Additionally, CD4+CX3CR1+ T cells compared to CD4+CX3CR1− T cells were the major producers of IFNγ with (8.0 ± 1.02% vs 1.6 ± 0.4%; p = 0.0001) or without (4.4 ± 0.7% vs 0.2 ± 0.1%; p = 0.0005) HIV infection (Fig. 1b and c- Lower panel). Here, CD4 is linked to HIV infectious disease.