Since TIGAR is important for NADPH generation in glioblastoma cells exposed to irradiation14, and NADPH is essential for both TrxR1 and GSH-Grx system, it is speculated that TIGAR abrogation combined with irradiation may deplete the NADPH level in TrxR1-overexpressing glioma cells, hence abrogated the reductive activity of Trx1 without a backup role of GSH-Grx system. The gene discussed is TIGAR; the disease is glioma.