TTR and amyloidosis: Despite the subject did not exhibit any evident symptom that could be associated with TTR amyloidosis, because mutations in this cavity have been shown to exert a strong impact on the tetramer stability, we decided to analyse the global TTR stability in the plasma of this person using native PAGE and Isoelectric Focusing (IEF) under semi-denaturing conditions (4 M Urea)24 (Fig. 1).