There was a clear difference in the antibody levels observed in healthy controls vs TB patients (PrSS5 < 0.001, PrSS1 < 0.001, PrSS4 < 0.001, PrSS2 < 0.001 and PrSS3 < 0.001, respectively) (Table 4; Fig. 4), However, rSS5, rSS1 and rSS4 antigens showed very good activity over other antigens in MDR-TB cases. This evidence concerns the gene PRSS2 and multidrug-resistant tuberculosis.