TNF-α has been found to increase permeability of the BBB [14] and high levels of TNF-α were found in active central and peripheral demyelinating lesions [32, 33] as well as in the serum, cerebrospinal fluid (CSF), and brain plaques of MS patients [34] correlating with disease severity or exacerbation [35, 36]. Here, TNF is linked to myeloid sarcoma.