Recently, Tar DNA-binding protein-43 (TDP-43) and Fused in Sarcoma (FUS), two proteins intimately linked to fronto-temporal dementia and related amyotrophic lateral sclerosis (FTD/ALS) have also been shown to disrupt ER–mitochondria associations [78, 79]. Here, TARDBP is linked to amyotrophic lateral sclerosis.