The function of GCs isolated from oocytes of young, middle-aged, and older infertile patients, as related to steroidogenesis, apoptosis, and gonadotropin activity during ovarian ovulation, was recently investigated by Wu et al. Similar to our study, GCs were collected form ovarian follicular fluid and the expression of FSHR, CYP19A1, HSD17B, LHR, CYP11A1, and PGR (progesterone receptor) was assessed. This evidence concerns the gene CYP11A1 and Infertility.