CXCL8 and endothelial dysfunction: The effects of MPs may vary between procoagulant and proinflammatory properties, induction of endothelial dysfunction by changes in nitric oxide (NO) levels and in the metabolic pathway of prostacyclin, decrease in expression of NO synthase (NOS), stimulation of cytokines release such as interleukin-8 (IL-8), IL-1β, IL-6, and tumor necrosis factor-α (TNF-α), and the expression of cell adhesion molecules [8, 9], among other actions, fundamental to the formation and development of atheromatous plaque [10].