For example, Walther et al. noted an association between a higher frequency of FOXP3− CD4+ IFN-γ+ IL-10+ effector T cells in the peripheral blood of children with uncomplicated compared to severe clinical malaria (100), while Jagannathan et al. identified an increased risk of future episodes of malaria in individuals with this same population of FOXP3− CD4+ IFN-γ+ IL-10+ T cells (101). The gene discussed is CD4; the disease is malaria.