REN and Increased circulating aldosterone concentration: Over all, the concomitant rise in cortisol and DOC, even though each of these molecules is intrinsically less potent than aldosterone at the mineralocorticoid receptor, will more than compensate the loss of aldosterone, and eventually create a state of chronic mineralocorticoid excess, best evidenced by the accompanying suppression of the renin plasma levels, a further—if not exclusive—contribution to the suppression of aldosterone secretion (30).