Today, CT-Scan allows to see the adrenal hyperplasia in vivo in patients with ACTH-dependent Cushing’s syndrome, and to observe its fate after the suppression of ACTH, that is after successful pituitary surgery: the two enlarged glands and the nodules progressively shrink and can even become atrophic until normal ACTH secretion is spontaneously restored, which may take months or years (37, 38). Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.