However, recent studies have shown that pertussis toxin, which is commonly injected as an adjuvant to increase EAE incidence, induced activation of a pyrin-dependent inflammasome (Dumas et al., 2014; Barclay and Shinohara, 2017), Therefore, the inflammasome sensor involved in MS/EAE might be not restricted to NLRP3. Here, NLRP3 is linked to myeloid sarcoma.