APP and Cerebral ischemia: The therapeutic potential of exogenous IL4 has been well documented in several CNS pathology models including models for spinal cord injury (Lee et al., 2010; Francos-Quijorna et al., 2016), APP/PS1 transgenic mice (Kiyota et al., 2010), cerebral ischemia (Zhao et al., 2015; Liu et al., 2016) as well as multiple sclerosis (Butti et al., 2008).