While specific mechanisms are difficult to discern with these clinical biomarker data, age related differences in BDNF secretion capacity (perhaps due to age-dependent risk factors like hypertension, cerebral hypoperfusion, and poor glucose metabolism) (Kennedy et al., 2009; Erickson et al., 2012), age related increases in CSF BDNF acutely (Failla et al., 2015), and also target receptor milieu (Erickson et al., 2012) may contribute to this finding. This evidence concerns the gene BDNF and Hypertension.