BDNF and hypertensive disorder: While specific mechanisms are difficult to discern with these clinical biomarker data, age related differences in BDNF secretion capacity (perhaps due to age-dependent risk factors like hypertension, cerebral hypoperfusion, and poor glucose metabolism) (Kennedy et al., 2009; Erickson et al., 2012), age related increases in CSF BDNF acutely (Failla et al., 2015), and also target receptor milieu (Erickson et al., 2012) may contribute to this finding.