EGFR and cancer: Some examples of proteins (oncogene mutation) most commonly mutated in cancer are: non-receptor tyrosine kinases (nRTKs; e.g. Src), receptor tyrosine kinases (RTK; e.g. EGFR, ErbB), serine/threonine kinases (e.g. Akt), transcription factors (e.g. NF-κB, Myc), small GTPases (e.g. Ras), lipid kinases (e.g. PI3K) and nuclear receptors (e.g. ER), cell cycle regulators (e.g. cyclins), and proliferative pathways (e.g. Wnt).