Importantly, AEG-1 expression in HCC is increased with the stages from I to IV as well as grades of the differentiation from well differentiated to poorly differentiated, which suggests AEG-1 is positively correlated with HCC development and metastasis (Ahn et al., 2013[1]; Li et al., 2015[16]). The gene discussed is MTDH; the disease is hepatocellular carcinoma.