Since we observed increased expression of LPC characteristics by inhibiting PHD proteins during HCC development, which was associated with increased mRNA expression of actors of the Notch pathway, we aimed to investigate if the effect of PHD2 haplodeficiency on liver tumour phenotype in advanced DEN induced HCC is preceded by altered LPC and/or Notch expression at early stages of hepatocarcinogenesis. Here, PDC is linked to hepatocellular carcinoma.