These observations are similar to the phenotype observed after PHD inhibition in HCC mice in previous studies (Heindryckx et al., 2012[16]; Bogaerts et al., 2015[1]) and as in human tumours recurring after TACE treatment (Zen et al., 2011[39]; Lai et al., 2015[22]). This evidence concerns the gene PDC and hepatocellular carcinoma.