Compared with clinical examinations such as direct sequencing of PCR-amplified genomic DNA, high-resolution melting analysis, fragment analysis, and the amplification refractory mutation system32, which are generally expensive and sometimes do not have a high rate of tumor cell detection, radiological features can not only discriminate EGFR-mutated subtypes (exon 19 deletion and exon 21 mutation) but are noninvasive and less expensive, especially for advanced NSCLC patients who cannot receive biopsy33. This evidence concerns the gene EGFR and non-small cell lung carcinoma.