Therefore, we chose 132 EGFR mutations in exon 19 (7.94%) and 140 in exon 21 (8.42%) from more than 1600 cases of lung adenocarcinoma, and found that the subtypes of EGFR mutation could be distinguished by the radiological features, which may prove to be helpful and useful to choose suitable patients and evaluate the clinical treatment. The gene discussed is EGFR; the disease is lung adenocarcinoma.