As shown in Table 3, of the patients with EGFR mutation in exon 21, there was a significantly higher percentage of maximum diameter (28.67 ± 14.45; p < 0.0001); sex (p < 0.0001); margins (p = 0.0095); GGO (p < 0.0001); density (p < 0.0001); vacuole sign (p = 0.0015); air bronchogram (p = 0.0361); satellite nodules in primary tumor lobe (p = 0.0431); pleural retraction (p = 0.0062); lesion location (p = 0.0024); fibrosis (p = 0.0262); pleural contact (p = 0.0013); pulmonary hilar lymph node enlargement (p = 0.0023); mediastinal lymph node enlargement (p = 0.0174); and smoking (p < 0.0001). Here, EGFR is linked to Lymphadenopathy.