Epidermal growth factor receptor (EGFR) is a protein in the same receptor family as HER2, which is overexpressed in many cancers, especially certain brain cancers.29 Like HER2, the receptor is a growth factor receptor, and as overexpression thus promotes tumor growth,30 it is in principle difficult for the tumors to escape EGFR targeted therapies. This evidence concerns the gene ERBB2 and cancer.