Epidermal growth factor receptor (EGFR) is a protein in the same receptor family as HER2, which is overexpressed in many cancers, especially certain brain cancers.29 Like HER2, the receptor is a growth factor receptor, and as overexpression thus promotes tumor growth,30 it is in principle difficult for the tumors to escape EGFR targeted therapies. The gene discussed is ERBB2; the disease is brain cancer.