HGF and lung carcinoma: DN30 is a monovalent chimeric Fab that induces the proteolytic cleavage of cMET, which causes the release of the soluble receptor and rapid proteasomal degradation of the intracellular portion.44 DN30 Fab reduces both HGF-dependent and HGF-independent tumor cell growth in vitro45 and delays tumor growth in preclinical models of human gastric cancer, lung carcinoma, and glioblastoma.