With these IgG1 molecules, heterodimeric IgG is produced using the controlled Fab-arm exchange method.34 JNJ-61186372 inhibits tumor cell growth by the downregulation of both EGFR and cMET in combination with enhanced antibody-dependent cell-mediated cytotoxicity.33, 35, 36, 37 Patients with NSCLC with EGFR mutations are being recruited for a phase I clinical study (NCT02609776). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.