This drug binds cMET without activating signal transduction and exerts anti-growth, anti-metastasis and anti-angiogenic actions in various cancer animal models.19 In preclinical studies, adenoviruses expressing the NK4 gene have demonstrated antitumor effects in numerous types of tumors including mesothelioma and pancreatic cancer.65, 66 A phase I clinical study of gene therapy using the NK4-expressing adenoviral vector in patients with mesothelioma is ongoing.67 This evidence concerns the gene IL32 and mesothelioma.