In recent years, a pivotal role of ACE2, ACE and their peptides were recognized during the inflammatory process such as glomerulonephritis, pulmonary hypertension, sepsis, lung injury, acute pancreatitis and also cardiac hypertrophy [37], while also being a key part of the renin–angiotensin system [38]. The gene discussed is ACE2; the disease is pulmonary hypertension.