The multibiomarker disease activity (MBDA) score is an RA disease activity measure based on serum concentrations of 12 protein biomarkers that include tumor necrosis factor receptor I (TNF-RI), interleukin 6 (IL-6), vascular cell adhesion molecule 1 (VCAM-1), epidermal growth factor (EGF), vascular endothelial growth factor A (VEGF-A), cartilage glycoprotein 39 (YKL40), matrix metalloproteinase 1 (MMP1), MMP3, serum amyloid A (SAA), leptin, and resistin [20]. This evidence concerns the gene CHI3L1 and rheumatoid arthritis.