In contrast, Wu et al. showed that midkine expression increased susceptibility of epithelial ovarian cancer cells to cisplatin/paclitaxel through down-regulated multidrug resistance-associated protein 3 and indicated that prognosis of the ovarian cancer patients with midkine-positive tumor cells was better than those with midkine-negative cells [34]. The gene discussed is ABCC3; the disease is ovarian carcinoma.