IL1R1 and lung disorder: Genes showing altered expression include a number of genes known to play important roles in lung disease such as α1-antitrypsin (SERPINA1) [25], transforming growth factor β 1 (TGFβI) [26], interleukin 1 receptor 1 (IL1R1) [27] and IL6, IL8, IL1B, IL1A [28–31].