PACAP has been shown to protect neurons against various noxious stimuli in vitro and in vivo [6,7,8] For example, PACAP is protective in traumatic brain [9] and spinal cord injury [10], in global and focal cerebral ischemia [6], in models of Huntington’s disease [11], and in Parkinson’s disease [12,13,14]. This evidence concerns the gene ADCYAP1 and Huntington disease.