PTGS2 and rheumatoid arthritis: Other examples include the cyclooxygenase-2 (COX-2)-specific non-specific anti-inflammatory drug rofecoxib (Vioxx), which proved to be enormously effective in providing powerful but transitory relief of pain in rheumatoid arthritis, but disrupted prostaglandin biosynthesis at levels that resulted in severe and occasionally fatal cardiotoxicity [20].