Authors analyzed the genetic variants that cause lifelong high BMI in FTO (fat mass and obesity-associated gene, rs9939609), MC4R (Melanocortin-4 Receptor gene, rs17782313) and TMEM18 (transmembrane protein 18, rs6548238) genes to evaluate the consequences of the obesity in COPD patients. This evidence concerns the gene TMEM18 and chronic obstructive pulmonary disease.