Authors analyzed the genetic variants that cause lifelong high BMI in FTO (fat mass and obesity-associated gene, rs9939609), MC4R (Melanocortin-4 Receptor gene, rs17782313) and TMEM18 (transmembrane protein 18, rs6548238) genes to evaluate the consequences of the obesity in COPD patients. The gene discussed is TMEM18; the disease is obesity due to melanocortin 4 receptor deficiency.