In an endothelial cell culture model of hyperglycemia, Storniolo et al. [85] showed that HT (10 μM) increases NO• production, which is correlated to an increase of endothelial nitric oxide synthase phosphorylation (P-eNOS)/endothelial nitric oxide synthase (eNOS) ratio. Here, NOS3 is linked to Hyperglycemia.