IL6 and infection: Hierarchical cluster and principal component analyses showed a gene expression profile for the TIME-K1 infection that was quite distinct from the other endothelial cell infections, with high levels of transcripts encoding K2 (viral IL-6), K8 (K-bZIP) and members of the ORF35–38 locus, including ORF36 which phosphorylates K-bZIP [75] and ORF37, the host shut-off protein [76].