EIF4E and fragile X syndrome: In addition, different responses for overactivated mTORC1 signaling in synaptic plasticity was observed depending on the ASD mouse model, i.e., mTORC1 may reduce mGluR-LTD in TSC [84] but enhance it in FXS [160,166] and eIF4E-NS-ASD [49,50], as well as decrease LTP in AS [44,45] and increase it in eIF4E-NS-ASD [49,50].