Interestingly, there is a tendency for those ASD forms with heightened mTORC1-dependent translation of synaptic proteins, such as FXS and eIF4E-NS-ASD, to display enhanced mGluR-LTD, whereas TSC, which show decreased mTORC1-dependent translation of synaptic proteins, exhibit impaired mGluR-LTD, suggesting that altered (either enhanced or reduced) mTORC1-mediated protein abundance of synaptic proteins, such as Arc, may influence mGluR-LTD and may be implicated in the synaptic defects and cognitive impairments associated with ASD pathogenesis across different genetic causes. The gene discussed is TSC1; the disease is Cognitive impairment.